로타바이러스는 전 세계 영유아에서 발생하는 중한 위장관염의 가장 흔한 원인 중 하나입니다.1
로타바이러스 감염에 의한 설사로 인한 사망은 5세 이하 영유아들의 사망 중 5%를 차지할 것이라고 예상됩니다.6,b
로타바이러스 위장관염을 일으키는 로타바이러스에는 여러 가지 유형이 있고, 지역/시기에 따라 유행 유형이 다양합니다.7,c
매년 유행하는 혈청형(유형)이 다를 수 있는 로타바이러스8,9
국내에서는 2008년부터 2010년까지 17가지 로타바이러스 혈청형**이 유행했습니다.8,d
매년 어떤 혈청형의 로타바이러스가 유행할지는 알 수 없습니다.9
* 2세까지 96%의 영아에서 로타바이러스에 적어도 한번 감염되었으며, 69%의 영아에서 2회, 42%의 영아에서 3회, 22%에서 4회, 13%에서 5회까지 로타바이러스 감염 발생
**G1,G2,G3,G4,G9P1A 혈청형은 한국에서 2008년 3월부터 2010년 2월까지 로타바이러스 위장관염으로 입원한 만 5세 미만 영유아에서 검출된 로타바이러스 혈청형의 98.66%에 해당되었습니다.
대한소아과학회. 예방접종지침서 제 9판. 2018
Jeong HS, Lee KB, Jeong AY, et al. Genotypes of the circulating rotavirus strains in the seven prevaccine seasons from September 2000 to August 2007 in South Korea. Clin Microbiol Infect. 2011;17(2):232–235.
Parashar UD et al. Global Illness and Deaths Caused by Rotavirus Disease in Children. Emerg Infect Dis. 2003;9(5):565-572.
NIH. MedlinePlus. Rotavirus infections. https://medlineplus.gov/rotavirusinfections.html. Accessed Mar 30, 2021.
Velazquez FR et al. Rotavirus infection in infants as protection against subsequent infections N Eng J Med. 1996;335:1022-1028
Tate JE, et al. 2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination
programmes: a systematic review and meta-analysis. Lancet Infect Dis. 2012;12:136- 141.
Banyai K et al. Systematic review of regional and temporal trends in global rotavirus strain diversity in the pre rotavirus vaccine era: Insights for understanding the impact
of rotavirus vaccination programs. Vaccine. 2012;30S:A122-A130
Shim JO, et al. Distribution of rotavirus G and P genotypes approximately two years following the introduction of rotavirus vaccines in South Korea. J Med Virol. 2013;85(7):1307-12
질병관리본부, 예방접종대상 감염병의 역학과 관리 제5판, 충북, 2017
Jeong et al Rotavirus infection PUBLIC HEALTH WEEKLY REPORT, CDC 2016: 931:611
200 Mexican infants from birth to two years of age monitored by weekly home visits and stool collections. The aims of this study were to determine the occurrence of primary (initial) and subsequent infections, to quantify the protective efficacy of natural symptomatic and asymptomatic rotavirus infections against subsequent infection and disease, and to compare the distribution of G types between initial and subsequent infections to assess whether protection against reinfection was related to the serotype. A physician assessed the severity of any episodes of diarrhea and collected additional stool specimens for testing by enzyme immunoassay and typing of strains. Serum collected during the first week of life and every four months thereafter was tested for antirotavirus IgA and IgG.
This study used PubMed to identify studies of at least 100 children younger than 5 years who had been admitted to hospital with diarrhoea. Specimens from 151 172 children younger than 5 years in 65 countries were tested as part of 131 studies that met our inclusion criteria. Additionally, this study required the studies to have a data collection midpoint of the year 2000 or later, to be done in full-year increments, and to assesses diarrhoea attributable to rotavirus with EIAs or polyacrylamide gel electrophoresis.
Data from countries that participated in the WHO-coordinated Global Rotavirus Surveillance Network (consisting of participating member states during 2009) and that met study criteria included. We classified studies into one of five groups on the basis of region and the level of child mortality in the country in which the study was done. For each group, to obtain estimates of rotavirus-associated mortality, we multiplied the random-effect mean rotavirus detection rate by the 2008 diarrhoea-related mortality figures for countries in that group. We derived the worldwide mortality estimate by summing our regional estimates.
This study is conducted with systematic search through PubMed for articles published in English from 1996 to August 2010 using the terms "rotavirus" in combination with "strain", "genotype" or "surveillance".
745 stool samples were collected from children under the age of 5 years. Children were hospitalized for acute gastroenteritis in three university hospitals located in Seoul, Incheon, and Gangwon provinces from Mar 2008 to Feb 2010. Genotyping of human rotaviruses was performed on 299 rotavirus-positive samples obtained from 745 stool samples
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